香港科技大学夏军教授招聘研究生及学术报告会

香港科技大学夏军教授招聘研究生及学术报告会
发信站: 瀚海星云 (2011年09月13日20:36:27 星期二), 站内信件 WWWPOST

【 以下文字转载自 LifeSciSchl 讨论区 】
【 原文由 emkeeper 所发表 】


香港科技大学生命科学部夏军教授有意从中国科大招收2012入学的硕博连读或直博生。
成绩优秀并有保送资格者可以豁免TOEFL 及GRE。夏军教授的研究方向见: http://life-sci.ust.hk/faculty/Dr.J.Xia/index.html
。有意者可将本科成绩单发到Email: jxia@ust.hk。夏军教授将于本周五周六（九月
16，17）访问中国科大，9月16日上午9：30在生命学院生物楼531会议室作如下讲座，欢
迎感兴趣的师生参加。另外，夏军教授将于9月16日下午和9月17日在生物楼531会议室举
行见面会，欢迎有意师从夏军教授的同学前去咨询。


Role of PICK1 and ICA69 Complex in Protein Trafficking and Diseases

Jun Xia

Division of Life Science, Hong Kong University of Science and Technology

Mammalian cells are divided by elaborate membrane compartments. Proteins are  
transported between different compartments via trafficking vesicles. Protein  
trafficking is tightly regulated to ensure proper function of different  
proteins. We identified PICK1, a peripheral membrane protein with a PDZ  
domain and a BAR domain, as an important protein trafficking regulator. The  
PDZ domain of PICK1 binds to a number of membrane proteins while the BAR  
domain of PICK1 binds to liposome and couple membrane proteins to  
trafficking vesicles. In addition, the BAR domain of PICK1 forms tight  
heteromeric BAR domain complex with ICA69, another BAR domain containing  
protein. The switch from heteromeric PICK1-ICA69 to homomeric PICK1-PICK1  
BAR domain complex provides an important mechanism for vesicle sorting and  
refinement. In brain, PICK1 interacts and regulates the trafficking of AMPA  
type glutamate receptor and this regulation is critical to synaptic  
plasticity, the cellular basis of learning and memory. In pancreatic beta-
cells, PICK1 controls the trafficking of insulin granules and its deficiency  
leads to glucose intolerance and symptoms related to diabetes.  

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※ 来源:·瀚海星云 bbs.ustc.edu.cn·[FROM: 211.86.157.124]

好消息.!!!!

好消息.谢谢楼主!